Borrowing from the cancer playbook: a master protocol basket trial for hard-to-heal wound therapeutics targeting shared pathobiology
Comparative Outcomes Amniotic Tissue Membrane Versus Standard Care in Diabetic Foot Ulcer Management: A Real-World Retrospective Cohort Study
Clinical Trial Protocol Windy Cole, DPM, CWSP, Dir. or Wound Care ResearchZweli Tuniswa, BA, Chief Exec. Officer & Co-FounderMarissa Docter, MD, BSN, RN, Chief Science Officer Objective:Hard-to-heal wounds, such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs), remain associated with poor healing outcomes despite optimised standard care. Although classified by aetiology, these wounds […]
A Multicenter Hybrid Platform Trial Evaluating Amniotic Tissue Grafts in Chronic Wounds: A Real-World Evidence Protocol for Diabetic Foot and Venous Leg Ulcers
Clinical Trial Protocol Windy Cole, DPMMarissa J. Carter, PhDCaroline E. Fife, MD, FAAFP, CWS, FUHMMarissa Docter, MD, BSN, RN November 2025ISSN 1943-2704Index 2025;37(11):445-450. doi:10.25270/wnds/25095 Abstract Background. Traditional randomized controlled trials of efficacy often lack generalizability due to strict inclusion criteria and controlled environments. Real-world evidence trials offer a complementary approach by evaluating the effectiveness of interventions in routine […]